ํ•œ๋ˆˆ์— ๋ณด๋Š” ์ฃผ์‹ ์ •๋ณด ํ”Œ๋žซํผ

๊ฒ€์ƒ‰

ํ•ญ์•”์ œ ์‹œ์žฅ์˜ ์ƒˆ๋กœ์šด ํŠธ๋ Œ๋“œ, ํ•ญ์ฒด์•ฝ๋ฌผ์ ‘ํ•ฉ์ฒด(ADC)
๋ฉ”์ธ ์ด๋ฏธ์ง€
ยฉ ์‚ผ์„ฑ๋ฐ”์ด์˜ค๋กœ์ง์Šค

ํ•ญ์•”์ œ ์‹œ์žฅ์˜ ์ƒˆ๋กœ์šด ํŠธ๋ Œ๋“œ, ํ•ญ์ฒด์•ฝ๋ฌผ์ ‘ํ•ฉ์ฒด(ADC)

๋”์šฑ ํšจ๊ณผ๊ฐ€ ์ข‹์€ ์น˜๋ฃŒ์ œ๋ฅผ ๋งŒ๋“ค๊ณ , ์น˜๋ฃŒ๊ฐ€ ๋ถˆ๊ฐ€๋Šฅํ•  ๊ฒƒ๋งŒ ๊ฐ™์€ ์งˆ๋ณ‘์„ ์น˜๋ฃŒํ•˜๊ณ ์ž ํ•˜๋Š” ๋…ธ๋ ฅ ๋•๋ถ„์— ์ œ์•ฝ ์‹œ์žฅ์˜ ํŠธ๋ Œ๋“œ๋Š” ๋น ๋ฅด๊ฒŒ ๋ณ€ํ™”ํ•ฉ๋‹ˆ๋‹ค. ํŠนํžˆ ์•„์ง ์ธ๋ฅ˜๊ฐ€ ์ •๋ณตํ•˜์ง€ ๋ชปํ•œ ์•”์„ ์น˜๋ฃŒํ•˜๊ธฐ ์œ„ํ•œ ํ•ญ์•”์ œ ๋ถ„์•ผ์—์„œ๋Š” ์ง€๊ธˆ๋„ ์น˜์—ดํ•œ ์—ฐ๊ตฌ๊ฐœ๋ฐœ์ด ์ง„ํ–‰ ์ค‘์ธ๋ฐ์š”. ๋ช‡ ๋…„ ์ „๋ถ€ํ„ฐ ํ•ญ์•”์ œ ์‹œ์žฅ์— ์ƒˆ๋กœ์šด ์น˜๋ฃŒ๋ฒ•์ด ๋“ฑ์žฅํ•ด ์ฃผ๋ชฉ๋ฐ›์Šต๋‹ˆ๋‹ค. ์˜ค๋Š˜์˜ ์ฃผ์ธ๊ณต, ํ•ญ์ฒด์•ฝ๋ฌผ์ ‘ํ•ฉ์ฒด(ADC)์ž…๋‹ˆ๋‹ค.


ํ•ญ์ฒด์•ฝ๋ฌผ์ ‘ํ•ฉ์ฒด(ADC)๋ž€?

๐Ÿ’Š ํ•ญ์ฒด์•ฝ๋ฌผ์ ‘ํ•ฉ์ฒด(ADC)์˜ ์ •์˜

ํ•ญ์ฒด์•ฝ๋ฌผ์ ‘ํ•ฉ์ฒด(Antibody-Drug Conjugate, ADC)๋Š” ํ•ญ์ฒด์™€ ์•ฝ๋ฌผ์„ ๊ฒฐํ•ฉํ•ด ๋งŒ๋“  ์น˜๋ฃŒ์ œ๋กœ, ํ‘œ์  ํ•ญ์•”์ œ์˜ ์ผ์ข…์ž…๋‹ˆ๋‹ค. ํ‘œ์  ํ•ญ์•”์ œ๋ž€ ์•”์„ธํฌ๋งŒ์„ ํ‘œ์ ์œผ๋กœ ํƒ€๊ฒŸํŒ…ํ•ด ์ฃฝ์ด๊ณ , ์ •์ƒ ์„ธํฌ์˜ ์†์ƒ์€ ์ตœ์†Œํ™”ํ•˜๋Š” ์•” ์น˜๋ฃŒ์ œ์ธ๋ฐ์š”. ADC๋Š” ์•”์„ธํฌ์— ๋ฐ˜์‘ํ•˜๋Š” ํ•ญ์ฒด์— ์•”์„ธํฌ๋ฅผ ์ฃฝ์ด๋Š” ์•ฝ๋ฌผ์„ ๋ถ™์ธ ๊ฒƒ์„ ๋œปํ•ฉ๋‹ˆ๋‹ค. ํ•ญ์ฒด๊ฐ€ ์•”์„ธํฌ๋ฅผ ์ฐพ์•„๊ฐ”์„ ๋•Œ ์•ฝ๋ฌผ์„ ํ’€์–ด ์•”์„ ์น˜๋ฃŒํ•˜๋Š” ๋ฐฉ์‹์ž…๋‹ˆ๋‹ค. ํ˜„์žฌ ADC๋Š” ํ•ญ์•” ์น˜๋ฃŒ์ œ์— ์ฃผ๋กœ ํ™œ์šฉ๋˜์ง€๋งŒ, ์‚ฌ์‹ค ์ด๋ก ์ ์œผ๋กœ๋Š” ๋‹ค๋ฅธ ์งˆ๋ณ‘ ์น˜๋ฃŒ์ œ์—๋„ ์–ผ๋งˆ๋“ ์ง€ ์ ์šฉ๋  ์ˆ˜ ์žˆ๊ธฐ๋„ ํ•œ๋ฐ์š”. ์œ ๋ง ๊ธฐ์ˆ ๋กœ์„œ ๋”์šฑ ์ฃผ๋ชฉ๋ฐ›๋Š” ์ด์œ ์ฃ .